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Aim and Objective: The main objective of this research was to formulate and evaluate gastroretentive-floating multiparticulate system of lisinopril to prolong the gastric residence time. Materials and Methods: Gastroretentive system of lisinopril was developed by ionotropic-gelation technique using isabgol (Plantago ovata F.) husk mucilage (IHM) as a floating agent, sodium alginate as a mucoadhesive polymer, and sodium bicarbonate as a gas-generating agent. Results: The beads were evaluated for entrapment efficiency (EE), in vitro drug release, and ex vivo mucoadhesion. The beads of batch F-2 exhibited high-EE (96.04 ± 0.74%), complete drug release (95.27 ± 0.12%), and good mucoadhesion (50% in 8 h). The in vitro drug release from these beads exhibited first-order kinetics that followed Higuchi diffusion model. Conclusion: The beads by virtue of the high EE, complete drug release, and good mucoadhesivity that exhibit prolonged gastric residence time are likely to improve the bioavailability of the drugs having the absorption window in proximal stomach.