Proximity labeling identifies a repertoire of site-specific R-loop modulators
oleh: Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including activity-dependent neuroprotective protein (ADNP). ADNP plays a role in R-loop resolution and loss-of-function leads to R-loop accumulation.