Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan
oleh: Giovanna Grigolon, Elisa Araldi, Reto Erni, Jia Yee Wu, Carolin Thomas, Marco La Fortezza, Beate Laube, Doris Pöhlmann, Markus Stoffel, Kim Zarse, Erick M. Carreira, Michael Ristow, Fabian Fischer
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Life- and healthspan of organisms can be modulated by dietary, genetic, or pharmacological interventions, which often affect metabolic pathways. Here the authors report that Grainyhead 1 is an evolutionarily conserved, drug-inducible transcription factor that promotes longevity in C. elegans, and thus a potential target for the development of geroprotective drugs.