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This study aims to systematically analyze and synthesize the literature produced thus far on cryptocurrency investment. We use a systematic review process supported by VOSviewer bibliographic coupling to review 482 papers published in the ABS 2021 journal list, considering all different areas of knowledge. This paper contributes an in-depth systematic analysis on the unconsolidated topic of cryptocurrency investment through the use of a cluster-based approach grounded in a bibliographic coupling analysis, revealing complex network associations within each cluster. Four literature clusters emerge from the cryptocurrency investment literature, namely, investigating investor behavior, portfolio diversification, cryptocurrency market microstructure, and risk management in cryptocurrency investment. Additionally, the study delivers a qualitative analysis that reveals the main conclusions and future research venues by cluster. The findings provide researchers with cluster-based information and structured networking for research outlets and literature strands.