Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
oleh: Yaping Chen, Ruyan Chen, Jinhuai Xu, Yongqi Tian, Jiangping Xu, Yonghong Liu
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2018-11-01 |
Deskripsi
Two novel altenusin-thiazole hybrids named altenusinoides A and B (<b>1</b> and <b>2</b>), a new benzothiazole derivative (<b>3</b>), and three known altenusin derivatives (<b>4</b>⁻<b>6</b>) have been obtained from the solid culture of the marine sponge-derived fungal strain, <i>Alternaria</i> sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds <b>1</b> and <b>2</b> possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound <b>3</b> represents the first benzothiazole derivative from fungi. Compounds <b>4</b> and <b>5</b> showed significant DPPH free-radical-scavenging activities with the prominent IC<sub>50</sub> values of 10.7 ± 0.09 μM and 100.6 ± 0.025 μM, respectively. Additionally, compound <b>5</b> exhibited COX-2 inhibitory activity with an IC<sub>50</sub> value of 9.5 ± 0.08 μM.