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Purpose: To describe a child with primary congenital glaucoma found to have pigment tissue proliferation in the angle following multiple applications of trans-scleral cyclophotocoagulation. Observations: During examination under anaesthesia, a 4-year-old girl was found to have pigmented tissue overlying the trabecular meshwork. Anterior segment ocular coherence tomography confirmed mounds of abnormal tissue in the angle. Conclusion: Trans-scleral cyclodiode may cause iris root damage, and predispose to proliferation of pigmented tissue which covers the angle structures. Keywords: Congenital glaucoma, Trabecular meshwork, Pigment proliferation, Cyclophotocoagulation