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Osimertinib‐related liver injury with successful osimertinib rechallenge: A case report
oleh: Yuan‐Ling Cheng, Wei‐Kuo Chang, Hao Yen, Yi‐Jen Peng, Wei‐Chou Chang, Ping‐Ying Chang
Format: | Article |
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Diterbitkan: | Wiley 2022-08-01 |
Deskripsi
Abstract Osimertinib is approved as the first‐line treatment for advanced non‐small cell lung cancer patients with epidermal growth factor (EGFR) mutation and for patients who develop EGFR T790M mutation during EGFR tyrosine kinase inhibitor (TKI) treatment and disease progression. Asymptomatic elevation of aminotransferase levels is commonly observed during TKI treatment; however, significant hepatotoxicity is infrequent. Here, we report a patient with osimertinib‐related drug‐induced liver injury who was successfully managed with osimertinib rechallenge.