Aplospojaveedins A–C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy
oleh: Ying Gao, Ying Gao, Marian Frank, Nicole Teusch, Dennis Woschko, Christoph Janiak, Attila Mándi, Tibor Kurtán, Rudolf Hartmann, Katja Schiedlauske, Lasse van Geelen, Rainer Kalscheuer, Jesko Kaiser, Christoph G. W. Gertzen, Holger Gohlke, Holger Gohlke, Bin-Gui Wang, Peter Proksch, Zhen Liu
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2024-09-01 |
Deskripsi
Three sulfur-containing alkaloids aplospojaveedins A–C (1–3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, α, β-unsaturated lactam and glycine-cysteine moieties were isolated from Aplosporella javeedii. Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT-ECD calculations. A plausible biosynthetic pathway and putative targets are described. The blind docking suggested that 1–3 may have functional effects on several putative targets such as the GPCR cannabinoid receptor 2 or the integrin α5β1 complex.