Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
oleh: Didier Dewailly, Anne-Laure Barbotin, Anne-Laure Barbotin, Agathe Dumont, Agathe Dumont, Sophie Catteau-Jonard, Sophie Catteau-Jonard, Geoffroy Robin, Geoffroy Robin, Geoffroy Robin
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2020-09-01 |
Deskripsi
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.