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<i>Aloe vera</i> has been proven to have various medicinal properties, including anti-inflammatory and anti-obesity functions. However, the effects of <i>Aloe vera</i>-fermented beverages (AFB) on obesity and its complications are still not clear. In this study, HepG2 cells in high-fat environment and high-fat diet (HFD) mice were used to investigate the potential obesity-preventing function of AFB. We found that AFB intervention decreased the amount of lipid droplets of HepG2 cells, suppressed the body weight gain and adipose accumulation, and reduced the serum contents of total cholesterol (TC), alanine aminotransferase (ALT), and interleukin 10 (IL-10) of HFD-mice. In addition, it also changed the composition of the gut microbiota. The ratio of <i>Firmicutes/Bacteroidetes</i> was decreased, while the relative abundance of <i>Muribaculaceae</i>, <i>Alistipes</i> and <i>Rikenellaceae_RC9_gut_group</i> was increased after the administration of AFB compared with HFD-mice. These results demonstrated that AFB can prevent diet-induced obesity (DIO) and provides a new option to modulate obesity-related gut dysbiosis.