Excess S-adenosylmethionine inhibits methylation via catabolism to adenine
oleh: Kazuki Fukumoto, Kakeru Ito, Benjamin Saer, George Taylor, Shiqi Ye, Mayu Yamano, Yuki Toriba, Andrew Hayes, Hitoshi Okamura, Jean-Michel Fustin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.