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One-pot condensation from aromatic aldehyde, methyl ketone, malononitrile and ammonium acetate in the presence of the ionic liquid (IL), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]), affords the corresponding 2-amino-4,6-diphenylpyridine-3-carbonitrile derivatives. This method has the advantage of short routine, high yields and being environmentally-friendly. Here, the need for catalyst is avoided through the use of catalytically active ionic liquid as solvent. Furthermore, the possible mechanism is also proposed.