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Two nitrogenous metabolites, bacillimide (<b>1</b>) and bacillapyrrole (<b>2</b>), were isolated from the culture broth of the marine-derived actinomycete <i>Streptomyces bacillaris</i>. Based on the results of combined spectroscopic and chemical analyses, the structure of bacillimide (<b>1</b>) was determined to be a new cyclopenta[<i>c</i>]pyrrole-1,3-dione bearing a methylsulfide group, while the previously reported bacillapyrrole (<b>2</b>) was fully characterized for the first time as a pyrrole-carboxamide bearing an alkyl sulfoxide side chain. Bacillimide (<b>1</b>) and bacillapyrrole (<b>2</b>) exerted moderate (IC₅₀ = 44.24 μM) and weak (IC₅₀ = 190.45 μM) inhibitory effects on <i>Candida albicans</i> isocitrate lyase, respectively. Based on the growth phenotype using <i>icl</i>-deletion mutants and <i>icl</i> expression analyses, we determined that bacillimide (<b>1</b>) inhibits the transcriptional level of <i>icl</i> in <i>C. albicans</i> under C₂-carbon-utilizing conditions.