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One of the main issues with complete dentures is their retention and stability while functioning. People would like to eat with their dentures on in a high-quality way, without having the feeling of the presence of a foreign body in their oral cavity. Another serious problem is the patients’ discomfort when they are fitted with new complete dentures and the impeded adaptation to them. On the Bulgarian and world markets, there are a lot of products aimed at eliminating these problems. Some of them are denture adhesives, also called gules or denture fixatives. There is a widely spread opinion they help only in case the dentures are often disconnected and are poorly wrought, but both a large part of the patients and some dental, medical doctors are not well acquainted with the advantages and shortcomings of denture adhesives; the indications and contraindications to their application. In Bulgaria, the most widely adopted denture adhesives are Corega, Protefix, Dental, Oradey, etc.