Lack of evidence for a genetic association between <it>FGF20 </it>and Parkinson's disease in Finnish and Greek patients
oleh: Hadjigeorgiou George M, Papadimitriou Alexandros, Peuralinna Terhi, Dardiotis Euthimios, Hellström Olli, Gourbali Vanesa, Eerola Johanna, Xiromerisiou Georgia, Clarimon Jordi, Tienari Pentti J, Singleton Andrew B
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2005-06-01 |
Deskripsi
<p>Abstract</p> <p>Background</p> <p>Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between <it>FGF20 </it>gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations.</p> <p>Methods</p> <p>Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland.</p> <p>Results</p> <p>No association was found in any of the populations studied.</p> <p>Conclusion</p> <p>Taken together, these findings suggest that common genetic variants in <it>FGF20 </it>are not a risk factor for PD in, at least, some European populations.</p>