Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation
oleh: Cristina T. Okamoto, Carlos F. Oldenburg Neto, Sandra Mara Witkowski, Ana Paula Percicote, Luca R. Pasqualotto, Gabriela Troiano, Tammy Almeida, Cleber M. Souza, Lúcia de Noronha
| Format: | Article |
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| Diterbitkan: | Sociedade Brasileira de Patologia Clínica |
Deskripsi
ABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature neonates that died with CLD. METHODS: Immunohistochemical analysis of 51 samples of premature newborn lungs – grouped in: without CLD,"classic" CLD and"new" CLD. RESULTS: Neutrophil influx and the number of CD4+ and CD45RO+ cells were higher in the"classic" CLD group (p < 0.001). CONCLUSION: Our findings suggest that the inflammatory response is mediated by neutrophils and CD45RO+ and CD4+ T lymphocytes in the"classic" CLD.