Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
oleh: David W.C. Beasley, C. Todd Davis, Jose Estrada-Franco, Roberto Navarro-Lopez, Arturo Campomanes-Cortes, Robert B. Tesh, Nikos Vasilakis, Alan D.T. Barrett
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2004-12-01 |
Deskripsi
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.