A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
oleh: Yanfeng Wang, Shaopeng Chi, Huifang Guo, Guang Li, Li Wang, Qiancheng Zhao, Yu Rao, Liansuo Zu, Wei He, Bailong Xiao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-04-01 |
Deskripsi
Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.