Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy
oleh: Orhan Ates, Habip Bilen, Sadullah Keles, H. Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Öndaş, L. Can Pınar, Mustafa Civelekler, Orhan Baykal
| Format: | Article |
|---|---|
| Diterbitkan: | Press of International Journal of Ophthalmology (IJO PRESS) 2013-10-01 |
Deskripsi
<b>AIM:</b> To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.<b>METHODS:</b> Patients with type 2 diabetes and PDRP were determined to be the case group (<i>n</i>=50). The control group was consist of healthy individuals (<i>n</i>=50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups.<b>RESULTS:</b> Ubiquinone-10 (Coenzyme Q10) levels in PDRP and control subjects are 3.81±1.19µmol/L and 1.91±0.62µmol/L, respectively. Plasma MDA levels in PDRP and control subjects were 8.16±2µmol/L and 3.44±2.08µmol/L, respectively. Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68, respectively.<b>CONCLUSION:</b>The ratio of ubiquinol-10/ubiquinone-10 is found lower in patients with PDRP. High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.