Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

oleh: Anne-Pauline Bellanger, Ana Berceanu, Emeline Scherer, Yohan Desbrosses, Etienne Daguindau, Steffi Rocchi, Laurence Millon

Format: Article
Diterbitkan: Centers for Disease Control and Prevention 2019-09-01

Deskripsi

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole–resistant Aspergillus fumigatus isolate and the other a Rhizomucor–A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.