ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
oleh: Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
ATRX is a chromatin remodeling protein, which loss has been associated to replication stress, DNA damage, and DNA repair failures that drive genome instability. Here the authors reveal that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.