Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
oleh: Eleonora Porcu, Sina Rüeger, Kaido Lepik, eQTLGen Consortium, BIOS Consortium, Federico A. Santoni, Alexandre Reymond, Zoltán Kutalik
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–trait associations.