Anionic phospholipids control mechanisms of GPCR-G protein recognition

oleh: Naveen Thakur, Arka P. Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V. Wijesekara, Zhan-Guo Gao, Christopher R. McCurdy, Kenneth A. Jacobson, Edward Lyman, Matthew T. Eddy

Format: Article
Diterbitkan: Nature Portfolio 2023-02-01

Deskripsi

In cell membranes, lipids are ubiquitous regulators of protein function. Here, Thakur et al. observe anionic phospholipids impact the conformational dynamics of a class A human GPCR.