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<p><strong>BACKGROUND</strong>: This study tried to develop an Asian Stroke Disability Scale (ASDS) and compared its interrater reliability with modified Rankin Scale (mRS) and Barthel Index (BI).</p> <p><strong>METHODS</strong>: Three items including self-care, mobility, and daily activities were selected as variables for development of the ASDS. The variables were provisionally graded on a 2- to 4-point scale based on the importance of each item. Each of the variables was categorized into 3 categories. Afterward, 125 rater-patient assessments for each scale (mRS, BI, and ASDS) were performed on 25 stroke patients by 5 raters. For categorization of functional impairment as minor or major, the scores of mRS, BI and ASDS were categorized as &le;2, &gt;2; &ge;90, &lt;90 and &lt;3, &ge;3, respectively.</p> <p>125 rater-patient assessments for each of the mRS, BI, and ASDS were performed on 25 stroke patients by five raters.</p> <p><strong>RESULTS</strong>: The quantitative variability of BI, mRS, and ASDS scores was not significant<strong> </strong>(P = 0.379; P = 0.780; and P = 0.835, respectively). Interrater variability of mRS, BI, and ASDS scores based on qualitative categorization was not significant (P = 1.000; P = 0.978; and P = 0.901, respectively). Paired interrater variability of mRS, BI, and ASDS scores based on qualitative categorization was not significant (P &gt; 0.05).</p> <p><strong>CONCLUSION: </strong>The ASDS is easy to use, requires less than 1 minute to complete and is as valid as mRS and BI in assessment of functional impairment of patients with stroke.</p> <strong>Keywords: </strong>Stroke, Disability, Scale, Validation <div><hr size="1" /></div>