Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis
oleh: Jennifer A. Bartell, Anna S. Blazier, Phillip Yen, Juliane C. Thøgersen, Lars Jelsbak, Joanna B. Goldberg, Jason A. Papin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-03-01 |
Deskripsi
Targeting virulence rather than bacterial growth is less likely to select for antibiotic resistance, but many possible targets function in both processes. Here, the authors reconstruct a genome-scale metabolic network ofP. aeruginosastrain PA14 and update that of strain PAO1, which, together with mutant screens, enable them to identify genes uniquely critical for virulence factor production.