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Fault detection is an important part of process supervision, especially in processes where there are strict requirements on the process outputs like in wastewater treatment. Statistical control charts such as Shewhart charts, cumulative sum (CUSUM) charts, and exponentially weighted moving average (EWMA) charts are common univariate fault detection methods. These methods have different strengths and weaknesses that are dependent on the characteristics of the fault. To account for this the methods in their base forms were tested with drift and bias sensor faults of different sizes to determine the overall performance of each method. Additionally, the faults were detected using two different sensors in the system to see how the presence of active process control influenced fault detectability. The EWMA method performed best for both fault types, specifically the drift faults, with a low false alarm rate and good detection time in comparison to the other methods. It was shown that decreasing the detection time can effectively reduce excess energy consumption caused by sensor faults. Additionally, it was shown that monitoring a manipulated variable has advantages over monitoring a controlled variable as set-point tracking hides faults on controlled variables; lower missed detection rates are observed using manipulated variables. HIGHLIGHTS The best fault detection performance was obtained with the EWMA chart.; Manipulated variable monitoring improves controlled variable sensor fault detection.; Fault detection in wastewater treatment processes can improve the energy efficiency.;