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[Purpose/Significance] This study aims to analyze the relationship between open science and intellectual property rights (IPRs) and systematically sort out the main intellectual property problems in open science, so as to provide reference for further promoting the formulation of intellectual property laws and policies in open science. [Methods/Process] This paper mainly adopts the methods of literature review and bibliometric analysis. Based on the analysis of the related work on open science and IPRs, we explore the relationship between them and identify the main intellectual property problems and coping strategies in open science. [Results/Conclusions] Conflicts exist between open science and IPRs, but the conflicts are not unavoidable. Both sides should get involved in forming a positive interaction atmosphere, and establish the IPR system which can be adapted to open science. Currently, the major problems of IPRs in open science are focused on copyrights and patent rights. Meanwhile, hotspot issues include how to ensure a scientist is given preference if he or she is the first to make scientific discoveries and how to protect data owners' rights.