Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics
oleh: Jouliana Sadek, Michael G. Wuo, David Rooklin, Arthur Hauenstein, Seong Ho Hong, Archana Gautam, Hao Wu, Yingkai Zhang, Ethel Cesarman, Paramjit S. Arora
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
NF-κB signalling involves the scaffold protein NEMO, which can be bound by the oncoprotein vFLIP to promote cell survival and oncogenic transformation. Here the authors rationally engineer a tertiary protein mimic of NEMO to disrupt the vFLIP-NEMO interaction to induce cell death.