Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
oleh: Xavier Brenachot, Giorgio Ramadori, Rafael M. Ioris, Christelle Veyrat-Durebex, Jordi Altirriba, Ebru Aras, Sanda Ljubicic, Daisuke Kohno, Salvatore Fabbiano, Sophie Clement, Nicolas Goossens, Mirko Trajkovski, Sheila Harroch, Francesco Negro, Roberto Coppari
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production.