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We report on the case of a 54 years old man treating for a metastatic renal carcinoma who had experienced a dermatological toxicity referring to sunitinb intake. The antiangiogenic drug was delivered at a daily dose of 50mg for 4 weeks followed by two weeks of rest. By the second week of treatment the patient presented a nappy erythema evolving towards erosive lesions bleeding at mild friction and extending to the perianal and scrotal area, the process fulfilled the maximal intensity at 4 weeks and improved after the discontinuation of sunitinib. The patient refused the reintroduction of the drug. No skin biopsy was developed seeing that the lesions disappeared 4 weeks later.