T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
oleh: Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Jürgen Beck, Henrike Salié, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
The tumour microenvironment counteracts immune therapy in Glioblastomas. Authors show here, using spatially resolved and single cell transcriptomics, that dysfunctional T cells are induced by a myeloid cell subset via Interleukin-10 signalling, and inhibition of the downstream JAK/STAT pathway might restore glioblastoma immune therapy responsiveness.