The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core
oleh: Karthik V. Rajasekar, Konrad Zdanowski, Jun Yan, Jonathan T. S. Hopper, Marie-Louise R. Francis, Colin Seepersad, Connor Sharp, Ludovic Pecqueur, Jörn M. Werner, Carol V. Robinson, Shabaz Mohammed, Jennifer R. Potts, Colin Kleanthous
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-07-01 |
Deskripsi
Counteracting oxidative stress is essential in all organisms. Here, the authors outline a mechanism used by actinomycete bacteria in which oxidation of zinc-binding RsrA blocks its interaction with σR by sequestering hydrophobic residues used to bind σRwithin its own core.