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<b>Aim</b>: To conduct a one-stage multicenter study in South-Kazakhstan Region to obtain baseline prevalence of comorbidity of chronic noninfectious diseases and their risk factors.<br> <b>Material and methods:</b>&nbsp;1400 persons at the age of 18-69, living in the South-Kazakhstan region. Epidemiological part consisted of: interviewing, physical examination and laboratory tests. For statistical analysis were used MSAccess and SPSS22.0. computer programs.<br> <b>Results</b>: 12.7% of respondents in South-Kazakhstan region smoke, which statistically significantly less than number of nonsmoking (87.3%; p&lt;0.01) ones. The number of alcohol drinkers is 28.4%, which also less than number of nondrinkers (71.6%; p&lt;0.01). The 48.3% of people included in the study had physical inactivity, while 51.7% had sufficient physical activity.<br> More than half of respondents had abdominal obesity (67.9%), which higher than number of people without obesity (32.1%; p&lt;0.01). The 72.1% had chronic noninfectious diseases (1009 of 1400). Comorbidity with two diseases – 48.2% (676 of 1400). Most common disease was arterial hypertension (45.9%: 464 of 1009). Less common – chronic kidney disease (2.4%:24 of 1009). The most common comorbidity – arterial hypertension and diabetes mellitus (72.3%). The less common – obesity and chronic obstructive pulmonary diseases (2.3%).<br> <b>Conclusions:&nbsp;</b>1. The most common risk factors of chronic noninfectious diseases in South-Kazakhstan region are improper diet, obesity, physical inactivity.<br> 2. The frequency of chronic noninfectious diseases in South-Kazakhstan region was 72.1%. And the most common disease was arterial hypertension.<br> 3. The most common comorbidity – combination diabetes mellitus with arterial hypertension while the less common – combination obesity with chronic obstructive pulmonary disease.