An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells

oleh: Y. Bill Kim, Kevin T. Zhao, David B. Thompson, David R. Liu

Format: Article
Diterbitkan: Nature Portfolio 2019-07-01

Deskripsi

Inefficient delivery of proteins into mammalian cells limits their use in research and therapy. Here, the authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery of genome editing proteins into mammalian cells.