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Radiogenomics research is one of the most important applications of artificial intelligence in the field of medicine. It is a new booming emerging discipline recent years. It combines image omics and genomics to make relatively intuitive research on disease in a non-invasive and efficient way. This review introduces the definition, advantages, methods and application fields of imaging genomics. We highlight the research progress of radiogenomics in clear cell renal cell carcinoma, to achieve accurate diagnosis of cancer and make optimal individualized treatment regimen.