Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice
oleh: Jiaqi Sun, Yinong Huang, Jin Gong, Jiancheng Wang, Yubao Fan, Jianye Cai, Yi Wang, Yuan Qiu, Yili Wei, Chuanfeng Xiong, Jierui Chen, Bin Wang, Yuanchen Ma, Lihua Huang, Xiaoyong Chen, Shuwei Zheng, Weijun Huang, Qiong Ke, Tao Wang, Xiaoping Li, Wei Zhang, Andy Peng Xiang, Weiqiang Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Pericytes play an essential role in blood brain barrier (BBB) integrity. Here, the authors generate pericyte-like cells (PCs) from human pluripotent stem cells (hPSCs) which display functional properties and also promote BBB recovery in a mouse model of cerebral artery occlusion.