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Three new triterpenoids—spergulagenin B (<b>1</b>), spergulagenin C (<b>2</b>), and spergulagenin D (<b>3</b>)—were isolated from the aerial part of <i>Glinus oppositifolius</i>, along with 17 known compounds (<b>4</b>–<b>20</b>). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds <b>3</b>, <b>5</b>, <b>19</b>, and <b>20</b> were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC₅₀ values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds <b>3</b>, <b>5</b>, and <b>20</b> exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC₅₀ values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively.