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This paper aims at advancing on the validation of indicators of building concrete frames' sustainability from an integrated, life cycle perspective. A case study approach investigates (i) feasibility of comparing sustainability performance of different flooring systems; and (ii) similarity between environmental indicators trends for a typical flooring system and corresponding whole superstructure. Three residential buildings are analyzed, using either prestressed concrete flat (PCF) slabs or reinforced concrete waffle (RCW) slabs and flat beams exposed to a marine environment. SimaPro 7.3 supports calculation of the environmental indicators. Service life estimation is used to ensure functional equivalence and to form a basis for life cycle costing. PCF slabs showed best functional/technical and economic results but were outperformed by RCW slabs' environmental results. Most environmental indicators showed the same trend for both typical floor and whole superstructure.