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The computer swine disease diagnosis is an important tool for swine farming industry, but the traditional expert system cannot meet the requirement of practical application. To improve the situation, a swine disease ontology is constructed, which can model the knowledge of swine disease diagnosis into a concept system, and a mechanism that can save the ontology into relational database is established, further more a computer system is developed to implement ontology-based swine disease diagnosis, so make the diagnosis results extended and more precise.