Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives
oleh: Li-Ming Hu, Jian-Jun Tan, Cheng-Chu Zeng, Hong-Qiu He, Zi-Guo Jiao, Cun-Xin Wang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2010-03-01 |
Deskripsi
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.