Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.
oleh: Feng Liu, Chen-Xi He, Li-Jun Luo, Quan-Li Zou, Yong-Xu Zhao, Ratni Saini, San-Feng Han, Hans-Joachim Knölker, Li-Shun Wang, Bao-Xue Ge
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2013-01-01 |
Deskripsi
Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.