Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
oleh: Kazuki Tajima, Kenji Ikeda, Yuji Tanabe, Ella A. Thomson, Takeshi Yoneshiro, Yasuo Oguri, Marc D. Ferro, Ada S. Y. Poon, Shingo Kajimura
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocytes triggers a fat-specific “cold-mimetic” thermogenesis response protecting mice against diet-induced obesity.