A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
oleh: S. N. Gettinger, J. Choi, N. Mani, M. F. Sanmamed, I. Datar, Ryan Sowell, Victor Y. Du, E. Kaftan, S. Goldberg, W. Dong, D. Zelterman, K. Politi, P. Kavathas, S. Kaech, X. Yu, H. Zhao, J. Schlessinger, R. Lifton, D. L. Rimm, L. Chen, R. S. Herbst, K. A. Schalper
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to ICB.