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Transboundary Lake Ohrid between Albania and Macedonia (SE Europe, Fig. 1) is considered to be the oldest continuously existing lake in Europe with a likely age of three to five million years. The lake has a surface area of 360 km2 and is 289 m deep. An extraordinarily high degree of endemism, including more than 210 described endemic species (Fig. 2), makes the lake a unique aquatic ecosystem of worldwide importance. Due to its old age, Lake Ohrid is one of the very few lakes in the world representing a hot spot of evolution and a potential evolutionary reservoir enabling the survival of relict species (Albrecht and Wilke, 2008). Its importance was emphasized when the lake was declared a UNESCO World Heritage Site in 1979.