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The Dentinal Fluid (DF), often referred to as dentinal microcirculation, represents the interstitial fluid within the Dentinal Tubules (DT). Understanding the dynamics of DF is pivotal in comprehending the physiology and pathology of the dental pulp. The composition of the DF, including ions, proteins, and growth factors, plays a critical role in maintaining pulp vitality, but imbalances can lead to various pathological conditions, such as dental hypersensitivity, pulpitis and pulp necrosis. The present review provides insight into the multifaceted role of DF in endodontics, highlighting its significance in pulp nutrition, defense mechanisms, and the mediation of inflammatory responses. Furthermore, it explores the various pathologies that can disrupt the delicate balance of DF, leading to adverse clinical outcomes.