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AIM:To explore the curative effect of dacryocystorhinostomy under endoscopy with mitomycin for the treatment of chronic dacryocystitis. <p>METHODS: Totally 73 cases(78 eyes)with chronic dacryocystitis were treated with dacryocystorhinostomy under endoscopy with mitomycin and followed up for 6-12mo.<p>RESULTS: In the 73 patients, 66 cases with 70 eyes(90%)were cured, 2 cases with 3 eyes(4%)improved, 5 cases with 5 eyes(6%)not changed. In the recurrent 5 eyes, 2 eyes were treated under endoscopy to remove granulation, enlarge the opening, then anesthetic tube was placed after cotton sheet with 0.4g/L mitomycin was put on the incision for 5min.The rest 3 eyes were treated in superior hospital with laser, and all were successful. There was no severe complication observed. <p>CONCLUSION:Dacryocystorhinostomy under endoscopy with mitomycin for chronic dacryocystitis is effective.