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A new acylic jasplakinolide congener (<b>2</b>), another acyclic derivative requiring revision (<b>4</b>), together with two jasplakinolide derivatives including the parent compound jasplakinolide (<b>1</b>) were isolated from the Indonesian marine sponge <i>Jaspis splendens</i>. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (<b>1</b>). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC₅₀ values in the low micromolar to nanomolar range.