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Objective: The incidence of interstitial pregnancy (IP) has increased by using assisted reproductive technology, especially after ipsilateral salpingectomy. This review aimed to examine the current state of prevention, risk factors, diagnosis, and management of IP, based on the current literature. Data sources: We searched PubMed for English language articles published up to June 2018. The search terms included interstitial pregnancy, ectopic pregnancy or cornual pregnancy, angular pregnancy, and combinations of these terms. Study selection: Articles were obtained and reviewed to analyze risk factors, diagnosis, prevention, and management of IP. Results: Ipsilateral salpingectomy is the main high-risk factor of IP, especially after in vitro fertilization. Cornual suture at the time of salpingectomy helps to reduce the IP rate. Laparoscopic cornuostomy appears to be an effective treatment in intact cases, although it sometimes needs to be combined with methotrexate therapy in ruptured cases complicated by persistent disease. Keywords: Laparoscopic cornuostomy, Interstitial pregnancy, Cornual suture, Salpingectomy