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In this work, with a simple and mild method, 1,5-benzodiazepine compounds were synthesized using the condensation of o-phenylenediamine derivatives and liner and cyclic ketones in the presence of the metal-organic framework Zn3(BTC)2 in ethanol at 50 °C. All products with excellent yields (86-94%) were obtained. Nanoparticles Zn3(BTC)2 have the advantages such as non-toxic, stable in solvents and harsh conditions, easy synthesis, high activity, easy separation from the reaction mixture by filtering and recyclable without losing its activity. In this work, with a simple and mild method, 1,5-benzodiazepine compounds were synthesized using the condensation of o-phenylenediamine derivatives and liner and cyclic ketones in the presence of the metal-organic framework Zn3(BTC)2 in ethanol at 50 °C. All products with excellent yields (86-94%) were obtained. Nanoparticles Zn3(BTC)2 have the advantages such as non-toxic, stable in solvents and harsh conditions, easy synthesis, high activity, easy separation from the reaction mixture by filtering and recyclable without losing its activity.