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Production of fatty acid-derived biofuels and chemicals have garnered attention in recent years owing to their potential to replace petroleum and plant oil-derived products. Through the metabolic engineering of the fatty acid metabolism pathway, advanced fuels and chemicals such as free fatty acid, triacylglycerol, biodiesel, fatty alcohols, alkanes/alkene, R-3-hydroxybutyric acid, polyhydroxyalkanoates and flavonoids have been produced. The robustness, high tolerance to organic solvent, good reputation in industrial fermentations and excellent availability of genetic tools make the yeast <em>Saccharomyces cerevisiae</em> a suitable cell factory for fatty acid-derived biofuels and chemicals production. This review will describe the successful metabolic engineering strategies employed to produce the fatty acid-derived bio-products in <em>S. cerevisiae</em>, including the enhancement of precursors and co-factors supply, promotion of the enzyme expression and activity, elimination of competing pathways, and the improvement of strain tolerance.